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KMID : 0391520090170020247
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Journal of the Korean Child Neurology Society
2009 Volume.17 No. 2 p.247 ~ p.252
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A Case of Encephalitis Caused by Epstein-Barr Virus Infection
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Do Hyun-Jeong
Baek Jong-Geun
Yeom Jung-Sook
Park Ji-Sook
Park Eun-Sil
Seo Ji-Hyun
Lim Jae-Young
Park Chan-Hoo
Woo Hyang-Ok
Youn Hee-Shang
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Abstract
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An 11-year-old girl was diagnosed with encephalitis due to Epstein-Barr virus(EBV). She was admitted to our hospital due to convulsion and decreased consciousness after several days of fever, sore throat and headache. Cerebrospinal fluid analysis showed lymphocyte-dominant pleocytosis and markedly elevated levels of protein. Magnetic resonance imaging(MRI) finding was normal, except for marked leptomeningeal enhancement. Even though she had signs and symptoms of infectious mononucleosis, EBV infection could not be considered as the underlying cause of the encephalitis until IgM for the viral capsid antigen of EBV had been detected in her blood. After treatment with acyclovir, a high dose of methylprednisolone and intravenous immunoglobulin, the neurological symptoms improved rapidly. She has not suffered from any neurological complications in the four months since being discharged. EBV infection should be considered as the main etiology in cases of childhood encephalitis, although there is no evidence of infectious mononucleosis existed.
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KEYWORD
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Infectious mononucleosis, Epstein-Barr virus Infections, Encephalitis
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